turmeric extract factories
Curcumin is one of the main efficacy ingredients of traditional curmeric, which has high nutritional and efficacy value
Curcuma longa L. Turmeric plant, its root can be added to medicine, special gas fragrance, bitter taste, Xin, sexual temperature, spleen, liver meridian; with blood broken qi, meridian pain function, for chest and side pain, chest pain, dysmenorrhea, amenorrhea, disease, rheumatic shoulder and arm pain, swelling and pain
Curcumin [curcumin, 1,7-di- (4-hydroxy-5-methoxyphenyl) -1,6-heptradiene-3,5-dione] is a polyphenolic compound extracted from curic roots, one of the main active components of curmeric, with various pharmacological effects including antioxidant, anti-inflammatory, anti-antitumor and antiviral
In the metabolism of organisms, free radicals with highly oxidative active groups, such as superoxide anion radical (O 2), hydroxyl radical (· OH), hydrocarbon oxygen radical, nitrogen oxide, nitric oxide and hydrogen peroxide, which, as second messengers, regulate the cell signal transduction pathway by changing the redox state
What is turmeric extract factories
Curmeric is a perennial herb in the ginger family, also known as tureric, is a traditional medicine with homologous medicine and food.
The pharmacodynamic value of curmeric refers to its dry rhizome, widely cultivated in tropical and subtropical areas, in particular, in Southeast Asia and northern Australia, which is mainly distributed in China, Africa, the United States, Japan and other countries.
There are many turmeric areas in China, mainly in in Sichuan, Fujian, Hunan, Guangdong, Yunnan, Tibet, Guizhou and Taiwan.Curmeric taste is sweet, bitter, mild, into the heart, liver and spleen, has the effect of breaking blood, hemostasis.
Curmeric has a long history of medicinal use. In ancient Chinese medicine, it was commonly used to treat chest pain, amenorrhea, symptoms, rheumatic pain, drop and swelling pain.
Because of its antiseptic effect, it is also used to treat cuts, burns and bruises.In addition, because turmeric has good health effects, it is also used to assist in the treatment of diseases such as stomach pain and indigestion.In the field of modern traditional Chinese medicine, it is mainly used for the production of TCM preparations.
In the food field, turmeric serves as seasonings, such as curry powder
What is The main ingredient in the turmeric meal
The main components of curmeric are curcumin and volatile oil (curmeric), in addition, contain resins, sugar (arabose 1.1%, 12% fructose, glucose 28%), sterols (legosterol, -glusterol), polypeptides, fatty acids, monoacrylic acid, diacrylic acid, alkaloids and trace elements
What is Curcumin
Curcumin is distributed in the tubers of the erinae and contains around 3% – 6%.The content of curcumin varies in different parts of curmeric, with the highest content in the root, greater than 2%, followed by the root whiskers, measuring at about 0.488%, and the lowest part is the root block, containing only 0.023%
What industry can curcumin be applied to
Curcumin, as a natural pigment, curcumin is widely used in pastries, candy, drinks, intestinal products and canned food because of its strong colorism.
At present, most of the existing artificial pigment will cause certain harm to the human body, and curcumin, as a natural pigment, is almost non-toxic and harmless, and it is gradually replacing the artificial pigment
Curcumin and pulmonary fibrosis
Pulmonary fibrosis is a severe lung disease characterized by the accumulation of excessive extracellular matrix (extracellular matrix (ECM).In the early stage of pulmonary fibrosis, the affected lungs are mainly inflammatory cell infiltration, edema and congestion, and then converted to Alveolar epi-thelial cells (AEC), with abnormal proliferation of ECM producing cells
What is the structure of curcumin
Curcumin is a slightly acidic diphenylheptanene substance, is an extremely rare dione colored material, and a compound with special polyphenolic structure.
Curmeric commonly mentioned usually refers to the general names of curic (C21H20O6), demethoxycuric (C20H18O5) and dideoxycuric (C19H16O4) monomers.
What does curcumin look like
Curcumin is an orange crystal powder, slightly bitter, insoluble in water, and soluble in ethanol, propylene glycol, glacial acetic acid, and alkali solutions.
The alkaline material is reddish-brown and yellow under neutral and acidic conditions, so it can be used as an indicator of acid-base titration.Curcumin meets light, heat, iron ion and other unstable.
What is the physiological function of curcumin
Curcumin has physiological functions such as anti-inflammatory, anti-cancer, antioxidant, antibacterial, and antiviral, and has obvious effects on the treatment of a variety of diseases.
However, due to its low solubility and poor bioutilization, its utilization rate is low.
turmeric extract factories
Protective effects against brain injury
Complex mechanisms underlying secondary neuronal cell damage were reported after brain injury, including the toxicity of the excitatory amino acid, oxidative stress, inflammatory response, and apoptosis
turmeric extract factories : In a neonatal rat astrocyte oxidative stress damage model, curcumin regulates Nrf2-ARE signaling, enhances Nrf2 mRNA and protein expression, promotes Nrf2 nuclear translocation, activates the downstream antioxidant enzyme genes HO-1 and phase II metabolic enzyme genes, upregulates the HO-1 and-GCS mRNA and protein expression levels, and is protective against astrocytes
What is liposome
turmeric extract factories Liposomal liposomes are miniature vesicular bodies formed by sealing drugs in the lipid bilayer. They have the characteristics of low toxicity, cell affinity and targeting. Both hydrophilic and lipophilic drugs can be packaged into liposomes
turmeric extract factories At present, liposomes have been well used in the preparation of anti-tumor drugs, and the successfully listed varieties are taxol liposomes, polirubicin liposomes, daunoromycin liposome, cisplatin liposomes, and cyclosporin A liposomes.Since CUR is a poorly water-soluble drug, liposomes have been used as a drug delivery system to improve the therapeutic efficacy and safety of CUR.
curcumin(B) and bisdemethoxycurcumin(C)
Effect on hyperlipidemia of turmeric extract factories
turmeric extract factories :Hyperlipemia is the main risk factor for atherosclerotic disease, and studies show that hyperlipidemia rats are damage to oxidative stress, diminished antioxidant capacity and impaired vascular function
It has been shown that curcumin can upregulate the abdominal aortic Nrf2 expression in animal models, enhance the arterial ability to resist oxidative stress, reduce the pathological damage of the abdominal aorta, and reduce the blood lipid levels in rats with an acute hyperlipidemia model
Protective effects against liver and kidney injury
Curcumin unconjugates Nrf2 to Keap1, promotes the nuclear translocation of Nrf2, binds to the ARE gene, initiates the transcription of genes regulated by ARE, induces HO-1 production in the body, and has a protective effect against liver tissue.
turmeric extract factories It has been shown that curcumin regulates the Nrf2-ARE signaling pathway and upregulates GST, NQO1, and HO-1 expression in the liver, small intestine, and kidney of mice
Cardiocarocyte protective effect of turmeric extract factories
turmeric extract factories Inhibition of cardiomyocyte damage induced by oxidative stress effectively reduces myocardial ischemia and reperfusion injury
turmeric extract factories It has been shown that curcumin suppresses NF-B activation by upregulating HO-1 activity, maintains cellular oxidative redox balance, and reduces oxidative stress damage in cardiomyocytes
Anti-tumor effects of turmeric extract factories
It was shown that NF-B is closely associated with multiple tumorigenesis and has consistently high expression of NF-B in tumor cells
turmeric extract factories Moderate inhibition of NF-B activation may become a new technology and adjuvant measure for tumor-targeted therapy.In the in vitro oxidative damage to lung cancer cells (A549) model, curcumin can increase antioxidase activity, downregulate NF-B expression, antagonize the activation expression of AP-1 and NF-B, improve cellular superoxide dismutase (SOD), nitric oxide synthase (NOS) and glutathione peroxidase (GSH-Px) vitality, and reduce MDA volume, enhance cell antioxidant damage capacity, and achieve tumor inhibition
Protective effects against lung injury
In rats with sepsis and acute lung injury, Curcumin, by inhibiting downstream NF-B activation, The NF- κB DNA binding activity was decreased, NF- κB p65 protein and p-IKKser180 / βser181 protein expression in lung tissue nucleus, Serum levels of TNF-,
cell to cell adhesion molecules (ICAM-1), and macrophage inflammatory protein 2 (MIP-2), and the expression levels of TNF-, ICAM-1, and MIP-2 mRNA in lung tissues were reduced,
The activity of the SOD was increased, Minuloperoxidase (MPO) activity and MDA quantity reduction, Inhibiting lung inflammatory response and reduce oxidative stress damage in lung tissue
Protective effects on the nervous system
Parkinson’s disease (PD) is a common degenerative disease of the central nervous system. At present, it is believed that the causes of PD include genetic factors, environmental factors, excitatory toxins, oxidative stress, autoimmune factors, and apoptosis
Protective effects against kidney injury
turmeric extract factories The results showed that curcumin inhibited NF-B expression, decreased MDA amount, increased SOD and the prototype glutathione (GSH) activity, serum creatinine, TNF C, COX-2 and NF-B, inhibited inflammatory and oxidative stress responses, and reduced oxidative stress and inflammatory damage in CPB kidneys.
In addition, in the rat model of alcoholic liver injury, the serum alanine amino-transferase (ALT), aspartate transaminotransferase (AST) and alkaline phosphatase (ALP) levels in the curcumin treatment group were significantly reduced, which inhibited the expression of lipid peroxidation and NF-B, increased SOD activity in liver tissue, reduced MDA and NO volume, and reduced or prevented alcohol-induced liver injury
Protective effect on the intestinal mucosa
The intestinal mucosa has the barrier protective function to prevent the invasion of pathogenic pathogens and toxins, and is a relatively perfect functional isolation zone.In the rat intestinal mucosa
curcumin inhibited NF-B and p38 activity and nuclear transport, by enhancing the expression of inflammatory cytokines TNF-, IL-1 β mRNA, and ICAM-1 of mitogen-activated protein kinase IL-1), which reduces the MPO activity, and protected the permeability of the intestinal mucosa
Anti-liver fibrosis effect
turmeric extract factories Fibrosis refers to the liver injury process of excessive diffuse extracellular matrix deposition in the liver caused by various pathogenic factors and is the main pathogenic factor of cirrhosis, where NADPH NADPH oxidase 4 (NOX4) is a major source of ROS in tissue
Effect on chronic inflammation
turmeric extract factories Is curcumin able to inhibit endotoxin-induced inflammatory responses in vascular smooth muscle cells (VSMCs), It have shown that curcumin through NADPH oxidase / ROS signaling mediated by Toll-like receptor (TLR), Inhibiting the p22Phox mRNA and protein expression levels,
Lower the ROS levels, Effective antagonization of lipopolysaccharide (LPS) stimulates the secretion of TNF-and IL-1 caused by VSMCs cells, Inhibition of the LPS-induced overexpression of TLR4 and its downstream NADPH oxidase / reactive oxygen species signaling pathway expression
Protective effects on the nervous system
turmeric extract factories PD is a CNS disease with low and high fatality rate, characterized by progressive loss of dopaminergic in midbrain nigra neurons
It was confirmed that curcumin reduces the generation of microglia-derived ROS and protects against dopaminergic cells by inhibiting the activation of microglia NADPH oxidase
Protective effect on corneal neovasculature
turmeric extract factories The inhibitory effect of curcumin on neovascularization of rat keratoalkali burns and the effect on corneal NOX4 expression, studies showed that curcumin treatment downregulated NADPH expression, thus inhibiting the production of ROS, providing a basis for the clinical application of curcumin in keratoalkali burns
